The client is a 52 year-old male admitted to hospital for a bowel resection due to adenocarcinoma of the colon. He is one-day post-op. His hemoglobin is 74 g/L and the physician has ordered 2 units of packed red blood cells to be administered, each over two hours. He is very anxious about the transfusion. Once the transfusion commences, he develops hives on his chest. This causes his anxiety to increase. An order for IV Benadryl is obtained and the client’s condition stabilizes.